Selective Pressure by Rifampicin Modulates Mutation Rates and Evolutionary Trajectories of Mycobacterial Genomes

Resistance to the frontline antibiotic rifampicin constitutes a challenge to the treatment and control of tuberculosis. Here, we analyzed the mutational landscape of Mycobacterium smegmatis during long-term evolution with increasing concentrations of rifampicin, using a mutation accumulation assay c...

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Detalles Bibliográficos
Autores principales: Cebrián-Sastre, E., Chiner-Oms, A., Torres-Pérez, R., Comas, I., Oliveros, J. C., Blázquez, J., Castañeda-García, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433840/
https://www.ncbi.nlm.nih.gov/pubmed/37436169
http://dx.doi.org/10.1128/spectrum.01017-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433840/
https://www.ncbi.nlm.nih.gov/pubmed/37436169
http://dx.doi.org/10.1128/spectrum.01017-23

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