The Plasmodium Lactate/H(+) Transporter PfFNT Is Essential and Druggable In Vivo

Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l-lactate/H(+) from the cell. This transporter is a member of the strictly microbial formate-nitrite transporter (FNT) family and a novel putative drug target. Small, d...

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Detalles Bibliográficos
Autores principales: Davies, Heledd, Bergmann, Bärbel, Walloch, Philipp, Nerlich, Cornelius, Hansen, Christian, Wittlin, Sergio, Spielmann, Tobias, Treeck, Moritz, Beitz, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433847/
https://www.ncbi.nlm.nih.gov/pubmed/37428074
http://dx.doi.org/10.1128/aac.00356-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433847/
https://www.ncbi.nlm.nih.gov/pubmed/37428074
http://dx.doi.org/10.1128/aac.00356-23

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