Cargando…

The Plasmodium Lactate/H(+) Transporter PfFNT Is Essential and Druggable In Vivo

Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l-lactate/H(+) from the cell. This transporter is a member of the strictly microbial formate-nitrite transporter (FNT) family and a novel putative drug target. Small, d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davies, Heledd, Bergmann, Bärbel, Walloch, Philipp, Nerlich, Cornelius, Hansen, Christian, Wittlin, Sergio, Spielmann, Tobias, Treeck, Moritz, Beitz, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Mechanisms of Action: Physiological Effects
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433847/ https://www.ncbi.nlm.nih.gov/pubmed/37428074 http://dx.doi.org/10.1128/aac.00356-23

Ejemplares similares

Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale
por: Golldack, André, et al.
Publicado: (2017)

Cell-Free and Yeast-Based Production of the Malarial Lactate Transporter, PfFNT, Delivers Comparable Yield and Protein Quality
por: Hajek, Philipp, et al.
Publicado: (2019)

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens
por: Hapuarachchi, Sanduni V., et al.
Publicado: (2017)

Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism
por: Peng, Xi, et al.
Publicado: (2021)

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials
por: Nerlich, Cornelius, et al.
Publicado: (2021)

Pentafluoro‐3‐hydroxy‐pent‐2‐en‐1‐ones Potently Inhibit FNT‐Type Lactate Transporters from all Five Human‐Pathogenic Plasmodium Species
por: Walloch, Philipp, et al.
Publicado: (2021)

Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase
por: Tan, SooNee, et al.
Publicado: (2021)

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum
por: Cao, Pengxing, et al.
Publicado: (2017)

Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast
por: Moore, Catherine M., et al.
Publicado: (2022)

Imidazolopiperazines Kill both Rings and Dormant Rings in Wild-Type and K13 Artemisinin-Resistant Plasmodium falciparum In Vitro
por: Dembele, Laurent, et al.
Publicado: (2018)

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains
por: Yang, Tuo, et al.
Publicado: (2016)

Dephospho-Coenzyme A Kinase Is an Exploitable Drug Target against Plasmodium falciparum: Identification of Selective Inhibitors by High-Throughput Screening of a Large Chemical Compound Library
por: Nurkanto, Arif, et al.
Publicado: (2022)

Bactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus
por: Cartron, Michaël L., et al.
Publicado: (2014)

Bacterial Drug Tolerance under Clinical Conditions Is Governed by Anaerobic Adaptation but not Anaerobic Respiration
por: Hemsley, Claudia M., et al.
Publicado: (2014)

Antibiotic Streptolydigin Requires Noncatalytic Mg(2+) for Binding to RNA Polymerase
por: Zorov, Savva, et al.
Publicado: (2014)

Independence from Kinetoplast DNA Maintenance and Expression Is Associated with Multidrug Resistance in Trypanosoma brucei In Vitro
por: Gould, Matthew K., et al.
Publicado: (2014)

Antimicrobial Treatment Improves Mycobacterial Survival in Nonpermissive Growth Conditions
por: Turapov, Obolbek, et al.
Publicado: (2014)

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2015)

Eagle Effect in Nonreplicating Persister Mycobacteria
por: Wu, Mu-Lu, et al.
Publicado: (2015)

Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions
por: Boulanger, Simon, et al.
Publicado: (2015)

Ramoplanin at Bactericidal Concentrations Induces Bacterial Membrane Depolarization in Staphylococcus aureus
por: Cheng, Mu, et al.
Publicado: (2014)

Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
por: Vincent, Isabel M., et al.
Publicado: (2016)

Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria
por: Asli, Abdelhamid, et al.
Publicado: (2016)

Combined Systems Approaches Reveal a Multistage Mode of Action of a Marine Antimicrobial Peptide against Pathogenic Escherichia coli and Its Protective Effect against Bacterial Peritonitis and Endotoxemia
por: Wang, Xiumin, et al.
Publicado: (2016)

In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline
por: Tanaka, S. Ken, et al.
Publicado: (2016)

Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis
por: Prosser, Gareth A., et al.
Publicado: (2016)

Development of an In Vitro Assay for Detection of Drug-Induced Resuscitation-Promoting-Factor-Dependent Mycobacteria
por: Loraine, Jessica, et al.
Publicado: (2016)

Siderophore Cephalosporin Cefiderocol Utilizes Ferric Iron Transporter Systems for Antibacterial Activity against Pseudomonas aeruginosa
por: Ito, Akinobu, et al.
Publicado: (2016)

Pulmonary Deposition and Elimination of Liposomal Amikacin for Inhalation and Effect on Macrophage Function after Administration in Rats
por: Malinin, Vladimir, et al.
Publicado: (2016)

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase
por: Kundu, Subhashri, et al.
Publicado: (2016)

Interplay between Antibiotic Efficacy and Drug-Induced Lysis Underlies Enhanced Biofilm Formation at Subinhibitory Drug Concentrations
por: Yu, Wen, et al.
Publicado: (2017)

Hyperbaric Oxygen Sensitizes Anoxic Pseudomonas aeruginosa Biofilm to Ciprofloxacin
por: Kolpen, Mette, et al.
Publicado: (2017)

Translation Elongation Factor 4 (LepA) Contributes to Tetracycline Susceptibility by Stalling Elongating Ribosomes
por: Liu, Bin, et al.
Publicado: (2018)

Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
por: Wall, Richard J., et al.
Publicado: (2018)

Verapamil Targets Membrane Energetics in Mycobacterium tuberculosis
por: Chen, Chao, et al.
Publicado: (2018)

Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation
por: Cushion, Melanie T., et al.
Publicado: (2018)

Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine
por: Armitage, Emily G., et al.
Publicado: (2018)

Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
por: Fernández-García, Laura, et al.
Publicado: (2018)

Novel Zinc-Attenuating Compounds as Potent Broad-Spectrum Antifungal Agents with In Vitro and In Vivo Efficacy
por: Cohrt, Karen A. O'Hanlon, et al.
Publicado: (2018)

TonB-Dependent Receptor Repertoire of Pseudomonas aeruginosa for Uptake of Siderophore-Drug Conjugates
por: Luscher, Alexandre, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8rqgi0nlvsr2fa1m6oo6to3sdl