Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives

The neutropenic mouse infection model is extensively used to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of anti-infective agents. However, it is difficult to evaluate agents following intravenous (i.v.) infusions using this model. Furthermore, in many drug discovery programs, lead id...

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Detalles Bibliográficos
Autores principales: Yedle, Randhir, Reniguntla, Mahesh Kumar, Puttaswamy, Ramesh, Puttarangappa, Pradeep, Hiremath, Somashekharayya, Nanjundappa, Mahesh, Jayaraman, Ramesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433970/
https://www.ncbi.nlm.nih.gov/pubmed/37260385
http://dx.doi.org/10.1128/spectrum.00133-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433970/
https://www.ncbi.nlm.nih.gov/pubmed/37260385
http://dx.doi.org/10.1128/spectrum.00133-23

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