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Neutropenic Rat Thigh Infection Model for Evaluation of the Pharmacokinetics/Pharmacodynamics of Anti-Infectives

The neutropenic mouse infection model is extensively used to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of anti-infective agents. However, it is difficult to evaluate agents following intravenous (i.v.) infusions using this model. Furthermore, in many drug discovery programs, lead id...

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Detalles Bibliográficos
Autores principales:	Yedle, Randhir, Reniguntla, Mahesh Kumar, Puttaswamy, Ramesh, Puttarangappa, Pradeep, Hiremath, Somashekharayya, Nanjundappa, Mahesh, Jayaraman, Ramesh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433970/ https://www.ncbi.nlm.nih.gov/pubmed/37260385 http://dx.doi.org/10.1128/spectrum.00133-23

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