Molecular Characterization and Sterol Profiles Identify Nonsynonymous Mutations in ERG2 as a Major Mechanism Conferring Reduced Susceptibility to Amphotericin B in Candida kefyr

The molecular basis of reduced susceptibility to amphotericin B (rs-AMB) among any yeasts is poorly defined. Genetic alterations in genes involved in ergosterol biosynthesis and total cell sterols were investigated among clinical Candida kefyr isolates. C. kefyr isolates (n = 81) obtained from 74 pa...

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Detalles Bibliográficos
Autores principales: Asadzadeh, Mohammad, Alfouzan, Wadha, Parker, Josie E., Meis, Jacques F., Kelly, Steven L., Joseph, Leena, Ahmad, Suhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434000/
https://www.ncbi.nlm.nih.gov/pubmed/37358415
http://dx.doi.org/10.1128/spectrum.01474-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434000/
https://www.ncbi.nlm.nih.gov/pubmed/37358415
http://dx.doi.org/10.1128/spectrum.01474-23

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