Activator Protein-1 (AP-1) Signaling Inhibits the Growth of Ewing Sarcoma Cells in Response to DNA Replication Stress

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in the synthesis of deoxyribonucleosides and is required for DNA replication. Multiple types of cancer, including Ewing sarcoma tumors, are sensitive to RNR inhibitors or a reduction in the levels of either the RRM1 or RRM2 subunits of...

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Detalles Bibliográficos
Autores principales: Croushore, Emma E., Koppenhafer, Stacia L., Goss, Kelli L., Geary, Elizabeth L., Gordon, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
https://www.ncbi.nlm.nih.gov/pubmed/37599787
http://dx.doi.org/10.1158/2767-9764.CRC-23-0268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
https://www.ncbi.nlm.nih.gov/pubmed/37599787
http://dx.doi.org/10.1158/2767-9764.CRC-23-0268

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