TRPA1 and TPRV1 Ion Channels Are Required for Contact Lens-Induced Corneal Parainflammation and Can Modulate Levels of Resident Corneal Immune Cells

PURPOSE: Contact lens wear can induce corneal parainflammation involving CD11c+ cell responses (24 hours), γδ T cell responses (24 hours and 6 days), and IL-17-dependent Ly6G+ cell responses (6 days). Topical antibiotics blocked these CD11c+ responses. Because corneal CD11c+ responses to bacteria re...

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Detalles Bibliográficos
Autores principales: Datta, Ananya, Lee, Ji Hyun, Flandrin, Orneika, Horneman, Hart, Lee, Justin, Metruccio, Matteo M. E., Bautista, Diana, Evans, David J., Fleiszig, Suzanne M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434714/
https://www.ncbi.nlm.nih.gov/pubmed/37585189
http://dx.doi.org/10.1167/iovs.64.11.21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434714/
https://www.ncbi.nlm.nih.gov/pubmed/37585189
http://dx.doi.org/10.1167/iovs.64.11.21

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