Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein

Recent HIV-1 vaccine development has centered on “near native” soluble envelope glycoprotein (Env) trimers that are artificially stabilized laterally (between protomers) and apically (between gp120 and gp41). These mutations have been leveraged for use in membrane-expressed Env mRNA vaccines, althou...

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Detalles Bibliográficos
Autores principales: Tong, Tommy, D’Addabbo, Alessio, Xu, Jiamin, Chawla, Himanshi, Nguyen, Albert, Ochoa, Paola, Crispin, Max, Binley, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434953/
https://www.ncbi.nlm.nih.gov/pubmed/37549185
http://dx.doi.org/10.1371/journal.ppat.1011452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434953/
https://www.ncbi.nlm.nih.gov/pubmed/37549185
http://dx.doi.org/10.1371/journal.ppat.1011452

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