Topic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank

Many diseases show patterns of co-occurrence, possibly driven by systemic dysregulation of underlying processes affecting multiple traits. We have developed a method (treeLFA) for identifying such multimorbidities from routine health-care data, which combines topic modeling with an informative prior...

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Detalles Bibliográficos
Autores principales: Zhang, Yidong, Jiang, Xilin, Mentzer, Alexander J., McVean, Gil, Lunter, Gerton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435382/
https://www.ncbi.nlm.nih.gov/pubmed/37601973
http://dx.doi.org/10.1016/j.xgen.2023.100371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435382/
https://www.ncbi.nlm.nih.gov/pubmed/37601973
http://dx.doi.org/10.1016/j.xgen.2023.100371

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