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High-sensitive nascent transcript sequencing reveals BRD4-specific control of widespread enhancer and target gene transcription

Gene transcription by RNA polymerase II (Pol II) is under control of promoters and distal regulatory elements known as enhancers. Enhancers are themselves transcribed by Pol II correlating with their activity. How enhancer transcription is regulated and coordinated with transcription at target genes...

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Detalles Bibliográficos
Autores principales: Bressin, Annkatrin, Jasnovidova, Olga, Arnold, Mirjam, Altendorfer, Elisabeth, Trajkovski, Filip, Kratz, Thomas A., Handzlik, Joanna E., Hnisz, Denes, Mayer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435483/
https://www.ncbi.nlm.nih.gov/pubmed/37591883
http://dx.doi.org/10.1038/s41467-023-40633-y