The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain

MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset of diffuse large B-cell lymphomas. MYD88-L265...

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Detalles Bibliográficos
Autores principales: Minderman, Marthe, Lantermans, Hildo, van der Zwaan, Carmen, Hoogendijk, Arie J., van den Biggelaar, Maartje, Kersten, Marie José, Spaargaren, Marcel, Pals, Steven T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435502/
https://www.ncbi.nlm.nih.gov/pubmed/37591861
http://dx.doi.org/10.1038/s41408-023-00896-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435502/
https://www.ncbi.nlm.nih.gov/pubmed/37591861
http://dx.doi.org/10.1038/s41408-023-00896-6

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