p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

PPARα corepressor NCoR1 is a key regulator of fatty acid β-oxidation and ketogenesis. However, its regulatory mechanism is largely unknown. Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PAK4 phosphorylates NCoR1 at T1619/T2124, resulting in an incre...

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Detalles Bibliográficos
Autores principales: Shi, Min Yan, Yu, Hwang Chan, Han, Chang Yeob, Bang, In Hyuk, Park, Ho Sung, Jang, Kyu Yun, Lee, Sangkyu, Son, Jeong Bum, Kim, Nam Doo, Park, Byung-Hyun, Bae, Eun Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435519/
https://www.ncbi.nlm.nih.gov/pubmed/37591884
http://dx.doi.org/10.1038/s41467-023-40597-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435519/
https://www.ncbi.nlm.nih.gov/pubmed/37591884
http://dx.doi.org/10.1038/s41467-023-40597-z

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