Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells

Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic stem cells (LSCs). Whether TKI-treated CML LSCs remain metabol...

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Detalles Bibliográficos
Autores principales: Rattigan, Kevin M., Brabcova, Zuzana, Sarnello, Daniele, Zarou, Martha M., Roy, Kiron, Kwan, Ryan, de Beauchamp, Lucie, Dawson, Amy, Ianniciello, Angela, Khalaf, Ahmed, Kalkman, Eric R., Scott, Mary T., Dunn, Karen, Sumpton, David, Michie, Alison M., Copland, Mhairi, Tardito, Saverio, Gottlieb, Eyal, Vignir Helgason, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435520/
https://www.ncbi.nlm.nih.gov/pubmed/37591854
http://dx.doi.org/10.1038/s41467-023-40222-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435520/
https://www.ncbi.nlm.nih.gov/pubmed/37591854
http://dx.doi.org/10.1038/s41467-023-40222-z

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