Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation

Genome-wide association studies (GWAS) have linked hundreds of loci to cardiac diseases. However, in most loci the causal variants and their target genes remain unknown. We developed a combined experimental and analytical approach that integrates single cell epigenomics with GWAS to prioritize risk...

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Detalles Bibliográficos
Autores principales: Selewa, Alan, Luo, Kaixuan, Wasney, Michael, Smith, Linsin, Sun, Xiaotong, Tang, Chenwei, Eckart, Heather, Moskowitz, Ivan P., Basu, Anindita, He, Xin, Pott, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435551/
https://www.ncbi.nlm.nih.gov/pubmed/37591828
http://dx.doi.org/10.1038/s41467-023-40505-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435551/
https://www.ncbi.nlm.nih.gov/pubmed/37591828
http://dx.doi.org/10.1038/s41467-023-40505-5

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