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Diabetes impairs fracture healing through Foxo1 mediated disruption of ciliogenesis

Foxo1 upregulation is linked to defective fracture healing under diabetic conditions. Previous studies demonstrated that diabetes upregulates Foxo1 expression and activation and diabetes impairs ciliogenesis resulting in defective fracture repair. However, the mechanism by which diabetes causes cili...

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Detalles Bibliográficos
Autores principales: Chinipardaz, Zahra, Yuan, Gongsheng, Liu, Min, Graves, Dana T., Yang, Shuying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435563/
https://www.ncbi.nlm.nih.gov/pubmed/37591875
http://dx.doi.org/10.1038/s41420-023-01562-3