C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR) is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are poorly defined. To inform on these mechanisms we conducted a genome-wide screen for genes that are synthetic lethal wi...

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Detalles Bibliográficos
Autores principales: Sharma, Abhishek Bharadwaj, Ramlee, Muhammad Khairul, Kosmin, Joel, Higgs, Martin R., Wolstenholme, Amy, Ronson, George E., Jones, Dylan, Ebner, Daniel, Shamkhi, Noor, Sims, David, Wijnhoven, Paul W. G., Forment, Josep V., Gibbs-Seymour, Ian, Lakin, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435583/
https://www.ncbi.nlm.nih.gov/pubmed/37591890
http://dx.doi.org/10.1038/s41467-023-40779-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435583/
https://www.ncbi.nlm.nih.gov/pubmed/37591890
http://dx.doi.org/10.1038/s41467-023-40779-9

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