Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability

Chromosome instability (CIN) is a cancer hallmark that drives tumour heterogeneity, phenotypic adaptation, drug resistance and poor prognosis. High-grade serous ovarian cancer (HGSOC), one of the most chromosomally unstable tumour types, has a 5-year survival rate of only ~30% — largely due to late...

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Detalles Bibliográficos
Autores principales: Nelson, Louisa, Barnes, Bethany M., Tighe, Anthony, Littler, Samantha, Coulson-Gilmer, Camilla, Golder, Anya, Desai, Sudha, Morgan, Robert D., McGrail, Joanne C., Taylor, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435626/
https://www.ncbi.nlm.nih.gov/pubmed/37592171
http://dx.doi.org/10.1007/s10577-023-09731-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435626/
https://www.ncbi.nlm.nih.gov/pubmed/37592171
http://dx.doi.org/10.1007/s10577-023-09731-x

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