Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia

This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG and the D...

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Autores principales: Zhang, Chelsea, Chu, Andrew, Boriack, Richard, Collins, Robert, Xu, Jing, Oliver, Dwight, Zheng, Ruifang, Rakheja, Dinesh, Chen, Weina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435681/
https://www.ncbi.nlm.nih.gov/pubmed/37601838
http://dx.doi.org/10.1002/jha2.723
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author Zhang, Chelsea
Chu, Andrew
Boriack, Richard
Collins, Robert
Xu, Jing
Oliver, Dwight
Zheng, Ruifang
Rakheja, Dinesh
Chen, Weina
author_facet Zhang, Chelsea
Chu, Andrew
Boriack, Richard
Collins, Robert
Xu, Jing
Oliver, Dwight
Zheng, Ruifang
Rakheja, Dinesh
Chen, Weina
author_sort Zhang, Chelsea
collection PubMed
description This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG and the D/L ratio (D‐2HG/L‐2HG) are significantly higher in IDH (mutated) cases than in IDH (wild) cases. The optimal cutoff values to predict IDH mutations at 100% sensitivity (specificity 91%–94%) are >588 ng/mL for D‐2HG and >2.33 for the D/L ratio. Our study indicates that elevated serum D‐2HG and the D/L ratio may serve as noninvasive biomarkers of IDH mutation in AML.
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spelling pubmed-104356812023-08-19 Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia Zhang, Chelsea Chu, Andrew Boriack, Richard Collins, Robert Xu, Jing Oliver, Dwight Zheng, Ruifang Rakheja, Dinesh Chen, Weina EJHaem Short Reports This study investigates whether serum D‐2HG (D‐2‐hydroxyglutarate) produced by the mutated isocitrate dehydrogenase (IDH) can predict IDH mutations in acute myeloid leukemia (AML) at diagnosis. D‐2HG and L‐2HG are measured by liquid chromatography‐tandem mass spectrometry. D‐2HG, total 2HG and the D/L ratio (D‐2HG/L‐2HG) are significantly higher in IDH (mutated) cases than in IDH (wild) cases. The optimal cutoff values to predict IDH mutations at 100% sensitivity (specificity 91%–94%) are >588 ng/mL for D‐2HG and >2.33 for the D/L ratio. Our study indicates that elevated serum D‐2HG and the D/L ratio may serve as noninvasive biomarkers of IDH mutation in AML. John Wiley and Sons Inc. 2023-06-19 /pmc/articles/PMC10435681/ /pubmed/37601838 http://dx.doi.org/10.1002/jha2.723 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Zhang, Chelsea
Chu, Andrew
Boriack, Richard
Collins, Robert
Xu, Jing
Oliver, Dwight
Zheng, Ruifang
Rakheja, Dinesh
Chen, Weina
Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title_full Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title_fullStr Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title_full_unstemmed Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title_short Serum D‐2‐hydroxyglutarate and the ratio of D‐2HG/L‐2HG predict IDH mutation in acute myeloid leukemia
title_sort serum d‐2‐hydroxyglutarate and the ratio of d‐2hg/l‐2hg predict idh mutation in acute myeloid leukemia
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435681/
https://www.ncbi.nlm.nih.gov/pubmed/37601838
http://dx.doi.org/10.1002/jha2.723
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