A novel trivalent non-Fc anti-CD3 Collabody preferentially induces Th1 cell apoptosis in vitro and long-lasting remission in recent-onset diabetic NOD mice

Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. We generated a trivalent anti-mouse-CD3 Collabody,...

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Detalles Bibliográficos
Autores principales: Huang, Chuan-Chuan, Sung, Hsiang-Hsuan, Li, Hsiu-Chuan, Miaw, Shi-Chuen, Kung, John T., Chou, Min-Yuan, Wu-Hsieh, Betty A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435756/
https://www.ncbi.nlm.nih.gov/pubmed/37600814
http://dx.doi.org/10.3389/fimmu.2023.1201853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435756/
https://www.ncbi.nlm.nih.gov/pubmed/37600814
http://dx.doi.org/10.3389/fimmu.2023.1201853

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