PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor

Cap-dependent endonuclease (CEN) in the polymerase acidic protein (PA) of influenza A virus (IAV) represents a promising drug target due to its critical role in viral gene transcription. The CEN inhibitor, baloxavir marboxil (BXM), was approved in Japan and the US in 2018 and several other countries...

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Detalles Bibliográficos
Autores principales: Luo, Dan, Ye, Qing, Li, Rui-Ting, Zhou, Hang-Yu, Guo, Jing-Jing, Zhao, Suo-Qun, Zhang, Sen, Jiang, Tao, Deng, Yong-Qiang, Qin, Cheng-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wuhan Institute of Virology, Chinese Academy of Sciences 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436051/
https://www.ncbi.nlm.nih.gov/pubmed/37290559
http://dx.doi.org/10.1016/j.virs.2023.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436051/
https://www.ncbi.nlm.nih.gov/pubmed/37290559
http://dx.doi.org/10.1016/j.virs.2023.06.002

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