Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle

Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription. They are also established targets of cancer chemotherapy. Starting from the available c...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavlin, Matic, Herlah, Barbara, Valjavec, Katja, Perdih, Andrej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436251/
https://www.ncbi.nlm.nih.gov/pubmed/37602233
http://dx.doi.org/10.1016/j.csbj.2023.07.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436251/
https://www.ncbi.nlm.nih.gov/pubmed/37602233
http://dx.doi.org/10.1016/j.csbj.2023.07.019

Ejemplares similares