Sequence dependencies and mutation rates of localized mutational processes in cancer

BACKGROUND: Cancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often show nucleotide sequence and functional region preferences. As a result, some sequence contexts mutate at much higher rates than others, with additi...

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Detalles Bibliográficos
Autores principales: Poulsgaard, Gustav Alexander, Sørensen, Simon Grund, Juul, Randi Istrup, Nielsen, Morten Muhlig, Pedersen, Jakob Skou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436389/
https://www.ncbi.nlm.nih.gov/pubmed/37592287
http://dx.doi.org/10.1186/s13073-023-01217-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436389/
https://www.ncbi.nlm.nih.gov/pubmed/37592287
http://dx.doi.org/10.1186/s13073-023-01217-z

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