Cargando…

Sequence dependencies and mutation rates of localized mutational processes in cancer

BACKGROUND: Cancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often show nucleotide sequence and functional region preferences. As a result, some sequence contexts mutate at much higher rates than others, with additi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poulsgaard, Gustav Alexander, Sørensen, Simon Grund, Juul, Randi Istrup, Nielsen, Morten Muhlig, Pedersen, Jakob Skou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436389/ https://www.ncbi.nlm.nih.gov/pubmed/37592287 http://dx.doi.org/10.1186/s13073-023-01217-z

Ejemplares similares

The landscape and driver potential of site-specific hotspots across cancer genomes
por: Juul, Randi Istrup, et al.
Publicado: (2021)

Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns
por: Sørensen, Simon Grund, et al.
Publicado: (2023)

A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
por: Bertl, Johanna, et al.
Publicado: (2018)

Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
por: Juul, Malene, et al.
Publicado: (2017)

miRNA activity inferred from single cell mRNA expression
por: Nielsen, Morten Muhlig, et al.
Publicado: (2021)

Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
por: Hornshøj, Henrik, et al.
Publicado: (2018)

Regmex: a statistical tool for exploring motifs in ranked sequence lists from genomics experiments
por: Nielsen, Morten Muhlig, et al.
Publicado: (2018)

ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation
por: Juul, Malene, et al.
Publicado: (2019)

Identification of expressed and conserved human noncoding RNAs
por: Nielsen, Morten Muhlig, et al.
Publicado: (2014)

Widespread DNA hypomethylation and differential gene expression in Turner syndrome
por: Trolle, Christian, et al.
Publicado: (2016)

Epigenetic Silencing of LRP2 Is Associated with Dedifferentiation and Poor Survival in Multiple Solid Tumor Types
por: Rasmussen, Martin Q., et al.
Publicado: (2023)

Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer
por: Okholm, Trine Line Hauge, et al.
Publicado: (2017)

DNA hypermethylation and differential gene expression associated with Klinefelter syndrome
por: Skakkebæk, Anne, et al.
Publicado: (2018)

Explicit Theoretical Analysis of How the Rate of Exocytosis Depends on Local Control by Ca(2+) Channels
por: Montefusco, Francesco, et al.
Publicado: (2018)

Does Mutation Rate Depend on Itself?
por: Baer, Charles F
Publicado: (2008)

Temperature dependence of spontaneous mutation rates
por: Waldvogel, Ann-Marie, et al.
Publicado: (2021)

Molecular strategies to inhibit HIV-1 replication
por: Nielsen, Morten Hjuler, et al.
Publicado: (2005)

Evolution of Local Mutation Rate and Its Determinants
por: Terekhanova, Nadezhda V., et al.
Publicado: (2017)

Interpreting the Dependence of Mutation Rates on Age and Time
por: Gao, Ziyue, et al.
Publicado: (2016)

Coupling of receptor interference and a host-dependent post-binding entry deficiency in a gammaretroviral envelope protein
por: Bahrami, Shervin, et al.
Publicado: (2010)

circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA
por: Okholm, Trine Line Hauge, et al.
Publicado: (2023)

How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome
por: Oman, Madeleine, et al.
Publicado: (2022)

miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
por: Rasmussen, Mads Heilskov, et al.
Publicado: (2016)

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer
por: Jager, Myrthe, et al.
Publicado: (2019)

SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization
por: Damas, Nkerorema Djodji, et al.
Publicado: (2016)

Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression
por: Okholm, Trine Line Hauge, et al.
Publicado: (2020)

EMu: probabilistic inference of mutational processes and their localization in the cancer genome
por: Fischer, Andrej, et al.
Publicado: (2013)

Quantifying Influences on Intragenomic Mutation Rate
por: Simon, Helmut, et al.
Publicado: (2020)

Sign of selection on mutation rate modifiers depends on population size
por: Raynes, Yevgeniy, et al.
Publicado: (2018)

Escherichia coli Frameshift Mutation Rate Depends on the Chromosomal Context but Not on the GATC Content Near the Mutation Site
por: Martina, Mariana A., et al.
Publicado: (2012)

Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes
por: Narasimhan, Vagheesh M., et al.
Publicado: (2017)

Concomitant driver mutations in advanced EGFR-mutated non-small-cell lung cancer and their impact on erlotinib treatment
por: Jakobsen, Jan Nyrop, et al.
Publicado: (2018)

Whole-exome sequencing of a patient with severe and complex hemostatic abnormalities reveals a possible contributing frameshift mutation in C3AR1
por: Leinøe, Eva, et al.
Publicado: (2016)

Acromegaly according to the Danish National Registry of Patients: how valid are ICD diagnoses and how do patterns of registration affect the accuracy of registry data?
por: Dal, Jakob, et al.
Publicado: (2014)

epiG: statistical inference and profiling of DNA methylation from whole-genome bisulfite sequencing data
por: Vincent, Martin, et al.
Publicado: (2017)

Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome of Dictyostelium discoideum
por: Kucukyildirim, Sibel, et al.
Publicado: (2020)

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells
por: Robinson, Philip S., et al.
Publicado: (2022)

SNPest: a probabilistic graphical model for estimating genotypes
por: Lindgreen, Stinus, et al.
Publicado: (2014)

Both cell autonomous and non-autonomous processes modulate the association between replication timing and mutation rate
por: Vardi-Yaacov, Oriya, et al.
Publicado: (2023)

Identification of novel Bach2 transcripts and protein isoforms through tagging analysis of retroviral integrations in B-cell lymphomas
por: Liu, Jinghua, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_dsphhpcd1mj8h144enuhejbhqc