SIRT1 activation by 2,3,5,6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization

BACKGROUND: Neuroinflammation has been reported as a potential contributing factor to brain diseases, and is characterized by activated microglia with release of multiple inflammatory mediators. 2,3,5,6-Tetramethylpyrazine (TMP) is an active alkaloid in Ligusticum chuanxiong Hort. and has various bi...

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Detalles Bibliográficos
Autores principales: Chen, Yu, Peng, Fu, Yang, Chao, Hou, Huan, Xing, Ziwei, Chen, Junren, Liu, Li, Peng, Cheng, Li, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436537/
https://www.ncbi.nlm.nih.gov/pubmed/37600790
http://dx.doi.org/10.3389/fimmu.2023.1206513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436537/
https://www.ncbi.nlm.nih.gov/pubmed/37600790
http://dx.doi.org/10.3389/fimmu.2023.1206513

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