Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression and decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages as compared to other opiates in clinical trials, possibly du...

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Detalles Bibliográficos
Autores principales: Ye, Liang, Li, Chunmei, Jiang, Wanglin, Yang, Yifei, Wang, Wenyan, Zhu, Haibo, Hu, Zhengping, Li, Ning, Cen, Xiaobo, Wang, Hongbo, Tian, Jingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436550/
https://www.ncbi.nlm.nih.gov/pubmed/37601058
http://dx.doi.org/10.3389/fphar.2023.1218380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436550/
https://www.ncbi.nlm.nih.gov/pubmed/37601058
http://dx.doi.org/10.3389/fphar.2023.1218380

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