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Short-chain fatty acids in diseases
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which pro...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436623/ https://www.ncbi.nlm.nih.gov/pubmed/37596634 http://dx.doi.org/10.1186/s12964-023-01219-9 |
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author | Zhang, Dan Jian, Yong-Ping Zhang, Yu-Ning Li, Yao Gu, Li-Ting Sun, Hui-Hui Liu, Ming-Di Zhou, Hong-Lan Wang, Yi-Shu Xu, Zhi-Xiang |
author_facet | Zhang, Dan Jian, Yong-Ping Zhang, Yu-Ning Li, Yao Gu, Li-Ting Sun, Hui-Hui Liu, Ming-Di Zhou, Hong-Lan Wang, Yi-Shu Xu, Zhi-Xiang |
author_sort | Zhang, Dan |
collection | PubMed |
description | Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which promote cellular metabolism. An increasing number of studies have implicated metabolites produced by microorganisms as crucial executors of diet-based microbial influence on the host. SCFAs are important fuels for intestinal epithelial cells (IECs) and represent a major carbon flux from the diet, that is decomposed by the gut microbiota. SCFAs play a vital role in multiple molecular biological processes, such as promoting the secretion of glucagon-like peptide-1 by IECs to inhibit the elevation of blood glucose, increasing the expression of G protein-coupled receptors such as GPR41 and GPR43, and inhibiting histone deacetylases, which participate in the regulation of the proliferation, differentiation, and function of IECs. SCFAs affect intestinal motility, barrier function, and host metabolism. Furthermore, SCFAs play important regulatory roles in local, intermediate, and peripheral metabolisms. Acetate, propionate, and butyrate are the major SCFAs, they are involved in the regulation of immunity, apoptosis, inflammation, and lipid metabolism. Herein, we review the diverse functional roles of this major class of bacterial metabolites and reflect on their ability to affect intestine, metabolic, and other diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01219-9. |
format | Online Article Text |
id | pubmed-10436623 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-104366232023-08-19 Short-chain fatty acids in diseases Zhang, Dan Jian, Yong-Ping Zhang, Yu-Ning Li, Yao Gu, Li-Ting Sun, Hui-Hui Liu, Ming-Di Zhou, Hong-Lan Wang, Yi-Shu Xu, Zhi-Xiang Cell Commun Signal Review Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate transporters, such as monocarboxylate transporter 1 and sodium-coupled monocarboxylate transporter 1, which promote cellular metabolism. An increasing number of studies have implicated metabolites produced by microorganisms as crucial executors of diet-based microbial influence on the host. SCFAs are important fuels for intestinal epithelial cells (IECs) and represent a major carbon flux from the diet, that is decomposed by the gut microbiota. SCFAs play a vital role in multiple molecular biological processes, such as promoting the secretion of glucagon-like peptide-1 by IECs to inhibit the elevation of blood glucose, increasing the expression of G protein-coupled receptors such as GPR41 and GPR43, and inhibiting histone deacetylases, which participate in the regulation of the proliferation, differentiation, and function of IECs. SCFAs affect intestinal motility, barrier function, and host metabolism. Furthermore, SCFAs play important regulatory roles in local, intermediate, and peripheral metabolisms. Acetate, propionate, and butyrate are the major SCFAs, they are involved in the regulation of immunity, apoptosis, inflammation, and lipid metabolism. Herein, we review the diverse functional roles of this major class of bacterial metabolites and reflect on their ability to affect intestine, metabolic, and other diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-023-01219-9. BioMed Central 2023-08-18 /pmc/articles/PMC10436623/ /pubmed/37596634 http://dx.doi.org/10.1186/s12964-023-01219-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhang, Dan Jian, Yong-Ping Zhang, Yu-Ning Li, Yao Gu, Li-Ting Sun, Hui-Hui Liu, Ming-Di Zhou, Hong-Lan Wang, Yi-Shu Xu, Zhi-Xiang Short-chain fatty acids in diseases |
title | Short-chain fatty acids in diseases |
title_full | Short-chain fatty acids in diseases |
title_fullStr | Short-chain fatty acids in diseases |
title_full_unstemmed | Short-chain fatty acids in diseases |
title_short | Short-chain fatty acids in diseases |
title_sort | short-chain fatty acids in diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436623/ https://www.ncbi.nlm.nih.gov/pubmed/37596634 http://dx.doi.org/10.1186/s12964-023-01219-9 |
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