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Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App(NL−G−F) knock-in Alzheimer mice

BACKGROUND: Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against which there is presently no effective cure. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in the learning and memory process,...

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Detalles Bibliográficos
Autores principales: Tambaro, Simone, Mitra, Sumonto, Gera, Ruchi, Linderoth, Bengt, Wahlberg, Lars U., Darreh-Shori, Taher, Behbahani, Homira, Nilsson, Per, Eriksdotter, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436657/
https://www.ncbi.nlm.nih.gov/pubmed/37596686
http://dx.doi.org/10.1186/s13195-023-01282-x