Cargando…

Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App(NL−G−F) knock-in Alzheimer mice

BACKGROUND: Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against which there is presently no effective cure. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in the learning and memory process,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tambaro, Simone, Mitra, Sumonto, Gera, Ruchi, Linderoth, Bengt, Wahlberg, Lars U., Darreh-Shori, Taher, Behbahani, Homira, Nilsson, Per, Eriksdotter, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436657/ https://www.ncbi.nlm.nih.gov/pubmed/37596686 http://dx.doi.org/10.1186/s13195-023-01282-x

Ejemplares similares

Microglia Impairs Proliferation and Induces Senescence In-Vitro in NGF Releasing Cells Used in Encapsulated Cell Biodelivery for Alzheimer’s Disease Therapy
por: Mitra, Sumonto, et al.
Publicado: (2022)

Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy
por: Mitra, Sumonto, et al.
Publicado: (2021)

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF
por: Mitra, Sumonto, et al.
Publicado: (2019)

Fast Alpha Activity in EEG of Patients With Alzheimer’s Disease Is Paralleled by Changes in Cognition and Cholinergic Markers During Encapsulated Cell Biodelivery of Nerve Growth Factor
por: Eyjolfsdottir, Helga, et al.
Publicado: (2022)

Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device
por: Eyjolfsdottir, Helga, et al.
Publicado: (2016)

Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain
por: Darreh-Shori, Taher, et al.
Publicado: (2018)

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers
por: Mitra, Sumonto, et al.
Publicado: (2021)

CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment
por: Karami, Azadeh, et al.
Publicado: (2021)

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain
por: Wahlberg, Lars U., et al.
Publicado: (2020)

Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization
por: Kumar, Rajnish, et al.
Publicado: (2016)

Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway
por: Vijayaraghavan, Swetha, et al.
Publicado: (2013)

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer’s Disease
por: Karami, Azadeh, et al.
Publicado: (2019)

Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL
por: Panahi, Mahmod, et al.
Publicado: (2020)

Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening
por: Kumar, Rajnish, et al.
Publicado: (2017)

Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs
por: Kumar, Rajnish, et al.
Publicado: (2016)

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
por: Salas, Isabel H., et al.
Publicado: (2018)

Clinical translation of stem cell therapy in traumatic brain injury: the potential of encapsulated mesenchymal cell biodelivery of glucagon-like peptide-1
por: Heile, Anna, et al.
Publicado: (2011)

Editorial: Neurotrophins Biodelivery to CNS: Innovative Approaches for Disease-Modifying Therapy
por: Triaca, Viviana, et al.
Publicado: (2022)

Biodelivery of therapeutic extracellular vesicles: should mononuclear phagocytes always be feared?
por: Cieślik, Martyna, et al.
Publicado: (2023)

Age-Dependent Behavioral and Metabolic Assessment of App(NL−G−F/NL−G−F) Knock-in (KI) Mice
por: Wang, Shanshan, et al.
Publicado: (2022)

The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in App(NL-G-F) Knock-In Mice
por: Medina-Vera, Dina, et al.
Publicado: (2023)

Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas
por: Sinclair, Lindsey Isla, et al.
Publicado: (2019)

Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling
por: Baidya, Anurag TK, et al.
Publicado: (2022)

The two faces of synaptic failure in App(NL-G-F) knock-in mice
por: Latif-Hernandez, Amira, et al.
Publicado: (2020)

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP(NL-F/NL-F) knock-in mice
por: Shah, Disha, et al.
Publicado: (2018)

A high‐fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the App (NL−F/NL−F) knock‐in mouse model
por: Mazzei, Guianfranco, et al.
Publicado: (2021)

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation
por: Malmsten, Linn, et al.
Publicado: (2014)

Biomarkers in Alzheimer's Disease and Lewy Body Disorders with Dementia
por: Leyhe, Thomas, et al.
Publicado: (2013)

Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase
por: Kumar, Amit, et al.
Publicado: (2018)

Autophagy Impairment in App Knock-in Alzheimer’s Model Mice
por: Jiang, Richeng, et al.
Publicado: (2022)

Nerve Growth Factor Biodelivery: A Limiting Step in Moving Toward Extensive Clinical Application?
por: Alastra, Giuseppe, et al.
Publicado: (2021)

Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer’s Disease Status and Risk Genotype
por: Lana, Erica, et al.
Publicado: (2019)

Mitochondrial Alterations in Neurons Derived from the Murine App(NL-F) Knock-In Model of Alzheimer’s Disease
por: Dentoni, Giacomo, et al.
Publicado: (2022)

Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App(NL-G-F) Mice
por: Huang, Melissa, et al.
Publicado: (2022)

Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions
por: Teitsdottir, Unnur D., et al.
Publicado: (2020)

Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects
por: Teitsdottir, Unnur D., et al.
Publicado: (2022)

Encapsulated Intracerebral Hematoma Presenting as Cerebral Abscess
por: Yoon, Elise J, et al.
Publicado: (2021)

Translational potential of synaptic alterations in Alzheimer’s disease patients and amyloid precursor protein knock-in mice
por: Medina-Vera, Dina, et al.
Publicado: (2023)

SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling
por: Izumi, Hisanao, et al.
Publicado: (2020)

Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App(NL−F/NL−F) knock-in mouse model of Alzheimer’s disease
por: Andersson, Emelie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4j2vvebok89pjd34krp0dn7dk8