GTM-decon: guided-topic modeling of single-cell transcriptomes enables sub-cell-type and disease-subtype deconvolution of bulk transcriptomes

Cell-type composition is an important indicator of health. We present Guided Topic Model for deconvolution (GTM-decon) to automatically infer cell-type-specific gene topic distributions from single-cell RNA-seq data for deconvolving bulk transcriptomes. GTM-decon performs competitively on deconvolvi...

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Detalles Bibliográficos
Autores principales: Swapna, Lakshmipuram Seshadri, Huang, Michael, Li, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436670/
https://www.ncbi.nlm.nih.gov/pubmed/37596691
http://dx.doi.org/10.1186/s13059-023-03034-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10436670/
https://www.ncbi.nlm.nih.gov/pubmed/37596691
http://dx.doi.org/10.1186/s13059-023-03034-4

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