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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells
Neddylation is necessary for activation of Cullin-RING ligases (CRLs), which degrade various immune regulatory proteins. Our recent study showed that while depletion of neddylation E2–E3 pair Ube2f-Sag in regulatory T (T(reg)) cells had no obvious phenotype, the same depletion of either Ube2m or Rbx...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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AAAS
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437198/ https://www.ncbi.nlm.nih.gov/pubmed/37600496 http://dx.doi.org/10.34133/research.0212 |