Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with β-adrenergic receptor overactivation through restoring calcium handling and suppressing cardiomyocyte apoptosis

Background: Long-term β-adrenergic receptor (β-AR) activation can impair myocardial structure and function. Dapagliflozin (DAPA) has been reported to improve clinical prognosis in heart failure patients, whereas the exact mechanism remains unclear. Here, we investigated the effects of DAPA against β...

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Detalles Bibliográficos
Autores principales: Liu, Tao, Wu, Jinchun, Shi, Shaobo, Cui, Bo, Xiong, Feng, Yang, Shuang, Yan, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437211/
https://www.ncbi.nlm.nih.gov/pubmed/37589258
http://dx.doi.org/10.1177/14791641231197106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437211/
https://www.ncbi.nlm.nih.gov/pubmed/37589258
http://dx.doi.org/10.1177/14791641231197106

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