Structural analysis of the dual agonism at GLP-1R and GCGR

Glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR), two members of class B1 G protein–coupled receptors, play important roles in glucose homeostasis and energy metabolism. They share a high degree of sequence homology but have different functionalities. Unimolecular dual agonists...

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Detalles Bibliográficos
Autores principales: Li, Yang, Zhou, Qingtong, Dai, Antao, Zhao, Fenghui, Chang, Rulue, Ying, Tianlei, Wu, Beili, Yang, Dehua, Wang, Ming-Wei, Cong, Zhaotong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438375/
https://www.ncbi.nlm.nih.gov/pubmed/37549266
http://dx.doi.org/10.1073/pnas.2303696120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438375/
https://www.ncbi.nlm.nih.gov/pubmed/37549266
http://dx.doi.org/10.1073/pnas.2303696120

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