Cargando…

Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines

Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the broader implementation of mRNA therapeutics and vaccines is the development of technology to produce precisely define...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shepherd, Sarah J., Han, Xuexiang, Mukalel, Alvin J., El-Mayta, Rakan, Thatte, Ajay S., Wu, Jingyu, Padilla, Marshall S., Alameh, Mohamad-Gabriel, Srikumar, Neha, Lee, Daeyeon, Weissman, Drew, Issadore, David, Mitchell, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10438381/ https://www.ncbi.nlm.nih.gov/pubmed/37556502 http://dx.doi.org/10.1073/pnas.2303567120

Ejemplares similares

Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
por: Han, Xuexiang, et al.
Publicado: (2023)

Scalable and High-Throughput Top-Down Manufacturing of Optical Metasurfaces
por: Lee, Taejun, et al.
Publicado: (2020)

Robust Microfabrication of Highly Parallelized Three-Dimensional Microfluidics on Silicon
por: Yadavali, Sagar, et al.
Publicado: (2019)

An ionizable lipid toolbox for RNA delivery
por: Han, Xuexiang, et al.
Publicado: (2021)

Silicon and glass very large scale microfluidic droplet integration for terascale generation of polymer microparticles
por: Yadavali, Sagar, et al.
Publicado: (2018)

Surface Topography-Adaptive Robotic Superstructures for Biofilm Removal and Pathogen Detection on Human Teeth
por: Oh, Min Jun, et al.
Publicado: (2022)

Tip-Based Nanofabrication for Scalable Manufacturing
por: Hu, Huan, et al.
Publicado: (2017)

Scalable manufacturing of fibrous nanocomposites for multifunctional liquid sensing
por: Goodman, Sheila M, et al.
Publicado: (2021)

Continuous and scalable manufacture of amphibious energy yarns and textiles
por: Gong, Wei, et al.
Publicado: (2019)

Rapid and up-scalable manufacturing of gigahertz nanogap diodes
por: Loganathan, Kalaivanan, et al.
Publicado: (2022)

Scalable manufacturing platform for the production of PEGylated heme albumin
por: Savla, Chintan, et al.
Publicado: (2022)

Manufacturing Scalable Carbon Nanotube–Silicone/Kevlar Fabrics
por: Giri, Prakash, et al.
Publicado: (2023)

Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy
por: Butowska, Kamila, et al.
Publicado: (2023)

Bioprocess decision support tool for scalable manufacture of extracellular vesicles
por: Ng, Kelvin S., et al.
Publicado: (2018)

A Versatile and Robust Platform for the Scalable Manufacture of Biomimetic Nanovaccines
por: Hu, Hanze, et al.
Publicado: (2021)

Thermally-curable nanocomposite printing for the scalable manufacturing of dielectric metasurfaces
por: Kim, Wonjoong, et al.
Publicado: (2022)

Predicting High-Throughput Screening Results With Scalable Literature-Based Discovery Methods
por: Cohen, T, et al.
Publicado: (2014)

DIRAC: a Scalable Lightweight Architecture for High Throughput Computing
por: Garonne, V, et al.
Publicado: (2004)

DIRAC: A Scalable Lightweight Architecture for High Throughput Computing
por: Garonne, V, et al.
Publicado: (2004)

Scalable high-throughput identification of genetic targets by network filtering
por: Bevilacqua, Vitoantonio, et al.
Publicado: (2013)

Nanomaterial Delivery Systems for mRNA Vaccines
por: Buschmann, Michael D., et al.
Publicado: (2021)

Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks
por: Couto, Pedro Silva, et al.
Publicado: (2023)

Scalable hybrid chemical manufacture to photothermal therapy: PEG-capped phototransducers
por: Byeon, Jeong Hoon
Publicado: (2016)

The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors
por: Bayley, Rachel, et al.
Publicado: (2017)

A Scalable Manufacturing Approach to Single Dose Vaccination against HPV
por: Shao, Shuai, et al.
Publicado: (2021)

Scalable Continuous Manufacturing Process of Stereocomplex PLA by Twin-Screw Extrusion
por: Alhaj, Mohammed, et al.
Publicado: (2023)

Cardiac electrophysiological imaging systems scalable for high-throughput drug testing
por: Lee, Peter, et al.
Publicado: (2012)

A high-throughput pipeline for scalable kit-free RNA extraction
por: Han, Ping, et al.
Publicado: (2021)

A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays
por: Lutton, Rebecca E.M., et al.
Publicado: (2015)

Adoption of knowledge-graph best development practices for scalable and optimized manufacturing processes
por: Jawad, M.S., et al.
Publicado: (2023)

mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model
por: Sittplangkoon, Chutamath, et al.
Publicado: (2022)

Human pluripotent stem cell-derived products: Advances towards robust, scalable and cost-effective manufacturing strategies
por: Jenkins, Michael J, et al.
Publicado: (2015)

Immobilisation of Delta-like 1 ligand for the scalable and controlled manufacture of hematopoietic progenitor cells in a stirred bioreactor
por: Moore, Rebecca L. L., et al.
Publicado: (2017)

Scalable Manufacturing of Single Nanowire Devices Using Crack-Defined Shadow Mask Lithography
por: Enrico, Alessandro, et al.
Publicado: (2019)

Scalable Textile Manufacturing Methods for Fabricating Triboelectric Nanogenerators with Balanced Electrical and Wearable Properties
por: Gunawardhana, K. R. Sanjaya, et al.
Publicado: (2022)

Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing
por: Gatla, Himavanth, et al.
Publicado: (2022)

Scalable continuous-flow electroporation platform enabling T cell transfection for cellular therapy manufacturing
por: VanderBurgh, Jacob A., et al.
Publicado: (2023)

A mosquito AgTRIO mRNA vaccine contributes to immunity against malaria
por: Chuang, Yu-Min, et al.
Publicado: (2023)

Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials
por: Whitley, Jill, et al.
Publicado: (2022)

Scalable and High-Throughput In Vitro Vibratory Platform for Vocal Fold Tissue Engineering Applications
por: Biehl, Andreea, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3ua001954h5ljss7lk3qk16iir