Protease-independent control of parthanatos by HtrA2/Omi

HtrA2/Omi is a mitochondrial serine protease with ascribed pro-apoptotic as well as pro-necroptotic functions. Here, we establish that HtrA2/Omi also controls parthanatos, a third modality of regulated cell death. Deletion of HtrA2/Omi protects cells from parthanatos while reconstitution with the pr...

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Detalles Bibliográficos
Autores principales: Weiß, Jonas, Heib, Michelle, Korn, Thiemo, Hoyer, Justus, Fuchslocher Chico, Johaiber, Voigt, Susann, Koudelka, Tomas, Tholey, Andreas, Adam, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439076/
https://www.ncbi.nlm.nih.gov/pubmed/37594630
http://dx.doi.org/10.1007/s00018-023-04904-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439076/
https://www.ncbi.nlm.nih.gov/pubmed/37594630
http://dx.doi.org/10.1007/s00018-023-04904-7

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