A brainstem to circadian system circuit links Tau pathology to sundowning-related disturbances in an Alzheimer’s disease mouse model

Alzheimer’s disease (AD) patients exhibit progressive disruption of entrained circadian rhythms and an aberrant circadian input pathway may underlie such dysfunction. Here we examine AD-related pathology and circadian dysfunction in the APPSwe-Tau (TAPP) model of AD. We show these mice exhibit phase...

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Detalles Bibliográficos
Autores principales: Warfield, Andrew E., Gupta, Pooja, Ruhmann, Madison M., Jeffs, Quiana L., Guidone, Genevieve C., Rhymes, Hannah W., Thompson, McKenzi I., Todd, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439113/
https://www.ncbi.nlm.nih.gov/pubmed/37596279
http://dx.doi.org/10.1038/s41467-023-40546-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439113/
https://www.ncbi.nlm.nih.gov/pubmed/37596279
http://dx.doi.org/10.1038/s41467-023-40546-w

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