TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation

TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell-intrinsic inhibitory signals in T cells remains unclear. Here we show, by ana...

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Detalles Bibliográficos
Autores principales: Worboys, Jonathan D., Vowell, Katherine N., Hare, Roseanna K., Ambrose, Ashley R., Bertuzzi, Margherita, Conner, Michael A., Patel, Florence P., Zammit, William H., Gali-Moya, Judit, Hazime, Khodor S., Jones, Katherine L., Rey, Camille, Jonjic, Stipan, Rovis, Tihana Lenac, Tannahill, Gillian M., Cruz De Matos, Gabriela Dos Santos, Waight, Jeremy D., Davis, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439114/
https://www.ncbi.nlm.nih.gov/pubmed/37596248
http://dx.doi.org/10.1038/s41467-023-40755-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439114/
https://www.ncbi.nlm.nih.gov/pubmed/37596248
http://dx.doi.org/10.1038/s41467-023-40755-3

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