Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

The spatial organization of the tumor microenvironment has a profound impact on biology and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic analysis on HPV-negative oral squamous cell carcinoma (OSCC) to comprehensively characterize malignant cells in tumor c...

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Detalles Bibliográficos
Autores principales: Arora, Rohit, Cao, Christian, Kumar, Mehul, Sinha, Sarthak, Chanda, Ayan, McNeil, Reid, Samuel, Divya, Arora, Rahul K., Matthews, T. Wayne, Chandarana, Shamir, Hart, Robert, Dort, Joseph C., Biernaskie, Jeff, Neri, Paola, Hyrcza, Martin D., Bose, Pinaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439131/
https://www.ncbi.nlm.nih.gov/pubmed/37596273
http://dx.doi.org/10.1038/s41467-023-40271-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439131/
https://www.ncbi.nlm.nih.gov/pubmed/37596273
http://dx.doi.org/10.1038/s41467-023-40271-4

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