One-carbon metabolizing enzyme ALDH1L1 influences mitochondrial metabolism through 5-aminoimidazole-4-carboxamide ribonucleotide accumulation and serine depletion, contributing to tumor suppression

Tumor cells generally require large amounts of nucleotides, and thus activate de novo purine synthesis (dnPS). In the dnPS reactions, 10-formyltetrahydorofolate (10-fTHF) supplied by one-carbon metabolism is utilized as a formyl group donor. We focused on aldehyde dehydrogenase 1 family member L1 (A...

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Detalles Bibliográficos
Autores principales: Sasaki, Masato, Yamamoto, Kazuo, Ueda, Takeshi, Irokawa, Hayato, Takeda, Kouki, Sekine, Ryoya, Itoh, Fumie, Tanaka, Yutaka, Kuge, Shusuke, Shibata, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439146/
https://www.ncbi.nlm.nih.gov/pubmed/37596270
http://dx.doi.org/10.1038/s41598-023-38142-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439146/
https://www.ncbi.nlm.nih.gov/pubmed/37596270
http://dx.doi.org/10.1038/s41598-023-38142-5

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