Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer

Ferroptosis, a form of programed cell death, can be promoted by inhibitors of the xCT transporter (erastin) or GPX4 (RSL3). We found that GPX4, but not the xCT transporter, is selectively elevated in luminal breast cancer. Consistent with this observation, the majority of luminal breast cancer cell...

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Detalles Bibliográficos
Autores principales: Park, Soon Young, Jeong, Kang Jin, Poire, Alfonso, Zhang, Dong, Tsang, Yiu Huen, Blucher, Aurora S., Mills, Gordon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439209/
https://www.ncbi.nlm.nih.gov/pubmed/37596261
http://dx.doi.org/10.1038/s41419-023-06042-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439209/
https://www.ncbi.nlm.nih.gov/pubmed/37596261
http://dx.doi.org/10.1038/s41419-023-06042-1

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