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Reactivated endogenous retroviruses promote protein aggregate spreading

Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigen...

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Detalles Bibliográficos
Autores principales: Liu, Shu, Heumüller, Stefanie-Elisabeth, Hossinger, André, Müller, Stephan A., Buravlova, Oleksandra, Lichtenthaler, Stefan F., Denner, Philip, Vorberg, Ina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439213/
https://www.ncbi.nlm.nih.gov/pubmed/37596282
http://dx.doi.org/10.1038/s41467-023-40632-z