Crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing

Studies have suggested that MHC class I (MHC I) molecules fluctuate rapidly between numerous conformational states and these motions support peptide sampling. To date, MHC I intermediates are largely uncharacterized experimentally and remain elusive. Here, we present x-ray crystal structures of HLA-...

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Detalles Bibliográficos
Autores principales: Li, Lenong, Peng, Xubiao, Batliwala, Mansoor, Bouvier, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439229/
https://www.ncbi.nlm.nih.gov/pubmed/37596268
http://dx.doi.org/10.1038/s41467-023-40736-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439229/
https://www.ncbi.nlm.nih.gov/pubmed/37596268
http://dx.doi.org/10.1038/s41467-023-40736-6

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