Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease

New approaches are needed to treat people whose obesity and type 2 diabetes (T2D) are driven by specific mechanisms. We investigate a deletion on chromosome 16p11.2 (breakpoint 2–3 [BP2–3]) encompassing SH2B1, a mediator of leptin and insulin signaling. Phenome-wide association scans in the UK (N =...

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Detalles Bibliográficos
Autores principales: Hanssen, Ruth, Auwerx, Chiara, Jõeloo, Maarja, Sadler, Marie C., Henning, Elana, Keogh, Julia, Bounds, Rebecca, Smith, Miriam, Firth, Helen V., Kutalik, Zoltán, Farooqi, I. Sadaf, Reymond, Alexandre, Lawler, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439272/
https://www.ncbi.nlm.nih.gov/pubmed/37586323
http://dx.doi.org/10.1016/j.xcrm.2023.101155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439272/
https://www.ncbi.nlm.nih.gov/pubmed/37586323
http://dx.doi.org/10.1016/j.xcrm.2023.101155

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