VHH CDR-H3 conformation is determined by VH germline usage

VHHs or nanobodies are single antigen binding domains originating from camelid heavy-chain antibodies. They are used as diagnostic and research tools and in a variety of therapeutic molecules. Analyzing variable domain structures from llama and alpaca we found that VHHs can be classified into two la...

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Detalles Bibliográficos
Autores principales: Bahrami Dizicheh, Zahra, Chen, I-Ling, Koenig, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439903/
https://www.ncbi.nlm.nih.gov/pubmed/37598276
http://dx.doi.org/10.1038/s42003-023-05241-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439903/
https://www.ncbi.nlm.nih.gov/pubmed/37598276
http://dx.doi.org/10.1038/s42003-023-05241-y

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