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SCF(RMF) mediates degradation of the meiosis-specific recombinase DMC1

Meiotic recombination requires the specific RecA homolog DMC1 recombinase to stabilize strand exchange intermediates in most eukaryotes. Normal DMC1 levels are crucial for its function, yet the regulatory mechanisms of DMC1 stability are unknown in any organism. Here, we show that the degradation of...

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Detalles Bibliográficos
Autores principales: Xu, Wanyue, Yu, Yue, Jing, Juli, Wu, Zhen, Zhang, Xumin, You, Chenjiang, Ma, Hong, Copenhaver, Gregory P., He, Yan, Wang, Yingxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10439943/
https://www.ncbi.nlm.nih.gov/pubmed/37598222
http://dx.doi.org/10.1038/s41467-023-40799-5