SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

BACKGROUND: SIRT6, an important NAD(+)‐dependent protein, protects endothelial cells from inflammatory and oxidative stress injuries. However, the role of SIRT6 in cardiac microvascular endothelial cells (CMECs) under ischemia‒reperfusion injury (IRI) remains unclear. METHODS: The HUVECs model of ox...

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Detalles Bibliográficos
Autores principales: Guo, Zhenyang, Yu, Xueting, Zhao, Shuang, Zhong, Xin, Huang, Dong, Feng, Runyang, Li, Peng, Fang, Zheyan, Hu, Yiqing, Zhang, Zhentao, Abdurahman, Mukaddas, Huang, Lei, Zhao, Yun, Wang, Xiangdong, Ge, Junbo, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440057/
https://www.ncbi.nlm.nih.gov/pubmed/37598403
http://dx.doi.org/10.1002/ctm2.1377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440057/
https://www.ncbi.nlm.nih.gov/pubmed/37598403
http://dx.doi.org/10.1002/ctm2.1377

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