Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression

BACKGROUND: Osteoarthritis (OA), a common chronic joint disease, is characterized by cartilage degeneration and subchondral bone reconstruction. NF-κB signaling pathway-activated inflammation and NLRP3-induced pyroptosis play essential roles in the development of OA. In this study, we examine whethe...

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Detalles Bibliográficos
Autores principales: Zheng, Xiaohang, Qiu, Jianxin, Gao, Ning, Jiang, Ting, Li, Ze, Zhang, Weikang, Gong, Yuhang, Hong, Zhenghua, Hong, Huaxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440089/
https://www.ncbi.nlm.nih.gov/pubmed/37605762
http://dx.doi.org/10.2147/DDDT.S417598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440089/
https://www.ncbi.nlm.nih.gov/pubmed/37605762
http://dx.doi.org/10.2147/DDDT.S417598

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