Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

The biomolecular mechanisms that regulate tooth root development and odontoblast differentiation are poorly understood. We found that Atp6i deficient mice (Atp6i(−/−)) arrested tooth root formation, indicated by truncated Hertwig’s epithelial root sheath (HERS) progression. Furthermore, Atp6i defici...

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Detalles Bibliográficos
Autores principales: Wang, Jue, McVicar, Abigail, Chen, Yilin, Deng, Hong-Wen, Zhao, Zhihe, Chen, Wei, Li, Yi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440342/
https://www.ncbi.nlm.nih.gov/pubmed/37599332
http://dx.doi.org/10.1038/s41368-023-00235-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440342/
https://www.ncbi.nlm.nih.gov/pubmed/37599332
http://dx.doi.org/10.1038/s41368-023-00235-2

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