Design, synthesis and antitumour activity evaluation of novel dolutegravir derivatives

Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was examined, and most compounds showed good inhibitory ef...

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Detalles Bibliográficos
Autores principales: Hou, Xi-Xi, Mao, Long-Fei, Guo, Yajie, Lou, Chaoxuan, Wang, Lan, Li, Rui-Fang, Wang, Huili, Li, San-Qiang, Yang, Jian-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440426/
https://www.ncbi.nlm.nih.gov/pubmed/37608893
http://dx.doi.org/10.3389/fphar.2023.1238587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440426/
https://www.ncbi.nlm.nih.gov/pubmed/37608893
http://dx.doi.org/10.3389/fphar.2023.1238587

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