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Design, synthesis and antitumour activity evaluation of novel dolutegravir derivatives
Based on the modification of the structure of dolutegravir, we introduced 1,2,3-triazole moieties with different substituted groups and obtained a lot of novel dolutegravir derivatives. The activity of A549 cells treated with the derivatives was examined, and most compounds showed good inhibitory ef...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10440426/ https://www.ncbi.nlm.nih.gov/pubmed/37608893 http://dx.doi.org/10.3389/fphar.2023.1238587 |